Advanced Research Projects Agency for Health (ARPA-H) Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) Program
Key Dates
Due Date
-
Posted Date
-
Agency & Value
Agency
ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
Contract Value
Not provided
Codes & Classification
Solicitation Number
7599226SN106
NAICS
541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
Classification Code
AN13
Additional Details
The Advanced Research Projects Agency for Health (ARPA-H), operating under the Department of Health and Human Services and the National Institutes of Health, has released a presolicitation notice for its upcoming Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Program. This initiative is designed to engage small business concerns (SBCs) with advanced research and development (R&D) capabilities in addressing critical health challenges aligned with ARPA-H’s mission.
The primary objective of this procurement is to stimulate technological innovation, strengthen the role of small businesses in meeting federal R&D needs, foster participation by socially and economically disadvantaged and women-owned small businesses, and increase the commercialization of innovations derived from federal R&D investments. The program aims to drive competition, productivity, and economic growth by supporting the development and transition of cutting-edge health technologies into the private sector.
This presolicitation is informational only; it is not a formal request for proposals or solution summaries. All posted materials, including the draft solicitation and attachments, are subject to change. Feedback and questions regarding the draft are welcomed until May 6, 2026, at 5:00 PM ET, via the ARPA-H portal (https://solutions.arpa-h.gov/ask-a-question). Details about the Proposers Day event are available in the associated attachments.
The anticipated solicitation (75N99226R00002) will be posted on SAM.gov, with the release and closing dates yet to be determined. The procurement is classified under NAICS code 541715 (Research and Development in the Physical, Engineering, and Life Sciences, except Nanotechnology and Biotechnology), with Product Service Code AN13. The opportunity is set aside for small businesses as defined by SBA standards, specifically those with no more than 500 employees and meeting the ownership and operational criteria outlined in 13 C.F.R. § 121.702.
The scope of the anticipated solicitation encompasses several high-impact research topics, including:
1. **Development of an Annual Test to Inform Women About Their Future Fertility (ARPA-H 01):** This topic seeks the discovery of novel biomarkers and the development of an affordable, user-friendly diagnostic test to provide women with actionable fertility data, supporting informed childbearing decisions and advancing women’s health monitoring tools.
2. **Versatile Bioadhesives (ARPA-H 02):** The goal is to create multifunctional surgical glues with antimicrobial properties, controllable reversibility, and degradability, suitable for a range of tissues and organs. These innovations aim to address unmet clinical needs in managing surgical leaks and infections, supporting the implementation of bioprinted organs, and reducing medical costs.
3. **Universal Platform for Living Adaptive Toxin-removal (UNI-PLAT) (ARPA-H 03):** This topic focuses on developing a synthetic biology platform for programmable microbial chassis, initially targeting toxin removal in chronic disease management but adaptable for broader applications such as environmental remediation, biomanufacturing, and therapeutic discovery.
4. **Breaking Ground: The First Curative, Non-Invasive, Long-Lasting Therapy for Endometriosis (ARPA-H 04):** Proposers are expected to develop non-invasive therapeutics that address the root cause of endometriosis, aiming for curative outcomes with precise, targeted specificity to minimize adverse effects.
5. **ARPA-H Lineage Topic (ARPA-H 05):** This topic supports the advancement and commercialization of technologies originating from ARPA-H-funded efforts, providing small businesses with resources to complete development, explore secondary applications, and achieve market self-sufficiency.
6. **Rapid Comprehensive Diagnostic Test for Multi-System Autoimmune Disease (ARPA-H 06):** The objective is to develop rapid, novel diagnostic assays for multi-system autoimmune diseases, enabling primary care physicians to diagnose and predict disease manifestations, thereby improving patient referral and care pathways.
7. **Virtual Human Brain for the Development of Neurosurgical Robotics (ARPA-H 07):** This topic aims to create a high-resolution, anatomically accurate virtual human brain to advance AI-assisted intracranial microsurgery and improve patient outcomes.
The place of performance for this procurement is Washington, District of Columbia. The contracting entity is ARPA-H, with Steven Snyder as the primary point of contact ([email protected]).
Contractors considering this opportunity should note the focus on innovative, high-impact health solutions, the requirement for small business status, and the emphasis on commercialization potential. The program encourages participation from diverse small business entities and seeks to foster partnerships that can translate advanced research into practical, scalable health technologies.
For further details, including attachments and updates, interested parties should refer to the official SAM.gov listing (https://sam.gov/opp/e5df5c54038945e089a70a3597f385cb/view).
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